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All the experiments were performed in accordance with the guidelines established in the Principles of Laboratory Animal Care directive 86 609 EEC ; and conformed to local guidelines on the ethical use of animals. The wild-type mice Cstb + + ; and mice heterozygous for a disruption in the Cstb Cstb + - ; gene were purchased from The Jackson Laboratory 129SvJ strain, USA ; and were further crossed to generate homozygous Cstb ; mice in our animal facilities. All animals were allowed free access to food and water and were housed in a temperature- and light-controlled environment 12 h light-dark cycles ; . Altogether twenty Cstb mice and same number of sex matched wild-type mice were taken for the experiments at the age of 4 to months II, III, V ; . In the heterozygous mice study IV ; fourteen Cstb + - mice and twelve Cstb + + mice were used at the average age of 17 months.
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108. Downey C. Herbs, other drugs dnta as m x hah i o' l nel n w . -depth reports. 1-5. WWW: : onhealth accessed 16 Sept 1999 ; . 109. Research reviews: review articles. Herbalgram. 1999; 46: 33-4. 0 . Phytomedicines of Europe: Chemistry and Biological Activity. Washington, DC: American Chemical Society; 1998. 111. B d nK Ltr H rs bnfs at . ee eet e ts b and risks. J Nurs. 1999; 99: 14. Page R, Lawrence J. Potentiation of war far in by dong quai. Pharmacotherapy. 1999; 19: 870-6. Duke J. Handbook of Medicinal Herbs. 6th printing. Boca Raton: CRC Press, Inc.; 1988. 114. De Smet P. Health risks of herbal remedies. Drug Saf. 1995; 13: 81-93. Voelker R. Herbs and anesthesia quick uptakes. JAMA. 1999; 281 20 ; . WWW: : jama-ama-assn accessed 29 Sept 1999 ; . 116. WHO Monographs on Selected Medicinal Plants. Vol 1. Geneva: World Health Organization; 1999. 117. Newall C, Anderson L, Phillipson J. Herbal Medicines A Guide for HealthC a r e Pharmaceutical Press; 1996. 118. Grainger Bisset N, Ed. Herbal Drugs and Phytopharmaceuticals. London: CRC Press and Stuttgart: Medpharm; 1994. 119. Gaby A, Austin S, Batz F, Yarrell E, Brown D, Linger S, Eds. A-Z Guide to Drug-Herb-Vitamin Interactions. Rocklin, CA: Healthnotes, Inc; 1999 and wellbutrin.
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